Aminopyridine (dalfampridine) is an organic compound with the chemical formula H2NC5H4N. The molecule is one of the three isomeric amines of pyridine. It is used primarily as a research tool, in characterizing subtypes of potassium channel, and has also been used to manage some of the symptoms of multiple sclerosisFood and Drug Administration (FDA) approved the compound on January 22, 2010.
Dalfampridine is marketed as Ampyra (pronounced "am-PEER-ah," according to the maker's website) in the United States by Acorda Therapeutics and will be available in March 2010.
The largest scale industrial application of 4-aminopyridine is as a precursor to the drug pinacidil, which affects potassium ion channels.
In the laboratory, 4-AP is a useful pharmacological tool in studying various potassium conductances in physiology and biophysics. It is a relatively selective blocker of members of Kv1 (Shaker, KCNA) family of voltage-activated K+ channels. At concentration of 1 mM it selectively and reversibly inhibits Shaker channels without significant effect on other sodium, calcium, and potassium conductances. 4-Aminopyridine is also used as a bird control agent, under the trade name Avitrol; it causes convulsions and rarely death, depending on dosage. The use of 4-aminopyridine in bird control has been criticized by the Humane Society of the United States.
Summarize from:
http://en.wikipedia.org/wiki/4-Aminopyridine
Tags: for which it has orphan drug status in the United States under the INN fampridine (trade name Neurelan). It was undergoing Phase III clinical trials as of 2008and the U.S. Ampyra, What is Ampyra, Ampyra Wiki, Definition of Ampyra, Aminopyridine, Dalfampridine, Application Ampyra
Dalfampridine is marketed as Ampyra (pronounced "am-PEER-ah," according to the maker's website) in the United States by Acorda Therapeutics and will be available in March 2010.
The largest scale industrial application of 4-aminopyridine is as a precursor to the drug pinacidil, which affects potassium ion channels.
In the laboratory, 4-AP is a useful pharmacological tool in studying various potassium conductances in physiology and biophysics. It is a relatively selective blocker of members of Kv1 (Shaker, KCNA) family of voltage-activated K+ channels. At concentration of 1 mM it selectively and reversibly inhibits Shaker channels without significant effect on other sodium, calcium, and potassium conductances. 4-Aminopyridine is also used as a bird control agent, under the trade name Avitrol; it causes convulsions and rarely death, depending on dosage. The use of 4-aminopyridine in bird control has been criticized by the Humane Society of the United States.
Summarize from:
http://en.wikipedia.org/wiki/4-Aminopyridine
Tags: for which it has orphan drug status in the United States under the INN fampridine (trade name Neurelan). It was undergoing Phase III clinical trials as of 2008and the U.S. Ampyra, What is Ampyra, Ampyra Wiki, Definition of Ampyra, Aminopyridine, Dalfampridine, Application Ampyra
No comments:
Post a Comment